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. 2014 Dec 22:14:993.
doi: 10.1186/1471-2407-14-993.

Paclitaxel-induced neuropathy: potential association of MAPT and GSK3B genotypes

Susanna B Park, John B Kwok, Clement T Loy, Michael L Friedlander, Cindy S-Y Lin, Arun V Krishnan, Craig R Lewis, Matthew C Kiernan  1
Affiliations

Paclitaxel-induced neuropathy: potential association of MAPT and GSK3B genotypes

Susanna B Park et al. BMC Cancer. .

Abstract

Background: Paclitaxel treatment produces dose-limiting peripheral neurotoxicity, which adversely affects treatment and long-term outcomes. In the present study, the contribution of genetic polymorphisms to paclitaxel-induced neurotoxicity were assessed in 21 patients, focusing on polymorphisms involved in the tau-microtubule pathway, an important target of paclitaxel involved in neurotoxicity development.

Methods: Polymorphisms in the microtubule-associated protein tau (MAPT) gene (haplotype 1 and rs242557 polymorphism) and the glycogen synthase kinase-3β (GSK3β) gene (rs6438552 polymorphism) were investigated. Neurotoxicity was assessed using neuropathy grading scales, neurophysiological studies and patient questionnaires.

Results: A significant relationship between the GSK-3B rs6438552 polymorphism and paclitaxel-induced neurotoxicity was evident.

Conclusions: Polymorphisms in tau-associated genes may contribute to the development of paclitaxel-induced neurotoxicity, although larger series will be necessary to confirm these findings.

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Pre-publication history
    1. The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2407/14/993/prepub

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