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Review
. 2014 Sep;19(9):899-903.

Epidemiology of VIM-1-imipenem resistant Pseudomonas aeruginosa in Iran: A systematic review and meta-analysis

Mansour Sedighi  1 , Amin Salehi-Abargouei  2 , Golfam Oryan  1 , Jamshid Faghri  1
Affiliations
Review

Epidemiology of VIM-1-imipenem resistant Pseudomonas aeruginosa in Iran: A systematic review and meta-analysis

Mansour Sedighi et al. J Res Med Sci. 2014 Sep.

Abstract

Background: Pseudomonas aeruginosa is an opportunistic human pathogen which causes serious problems, especially in people who have immunodeficiency. Metallo beta-lactamase (MBL) resistance in this bacterium has led some difficulties in treating bacterial infections. MBLs are being reported with increasing frequency worldwide. The aim of the present systematic review and meta-analysis was to collect data about the relative frequency (RF) of VIM-1-imipenem resistant P. aeruginosa (VIM-1-IRPA) in different regions of Iran and report an overall prevalence if possible.

Materials and methods: PubMed, ISI web of science, Scopus and Google Scholar were searched using following key terms: "P. aeruginosa," "imipenem," "VIM-1" and "Iran" were. Articles/abstracts, which used clinical specimens and had done polymerase chain reaction to detect the VIM-1 gene of MBL genes, were included in this review. STATA SE version 11.2 (StataCorp, College Station, TX, USA) was used for statistical analysis.

Results: Out of 5457 results found, 10 articles were eligible to be included in our systematic review and meta-analysis. These studies were carried out in Tehran, Isfahan, Kurdistan, Ahvaz, Markazi and Northwest of Iran (Orumieh and Tabriz). Pooled estimation of 1972 P. aeruginosa samples showed that 13% (95% confidence interval = 10.5-16.5%]) of strains were VIM-1 positive. VIM-1-IRPA RF in different studies varied from 0% to 19.5% in Isfahan and Markazi provinces, respectively. We found a moderate heterogeneity (Chochran Q-test, P = 0.032, I-squared = 50.7%) of VIM-1-IRPA RF among studies.

Conclusion: According to the results of this study VIM-1-IRPA RF in Iran is in low-level Prevention strategies to reduce the prevalence rates of VIM-1 positive strains in Iran are needed.

Keywords: Imipenem resistant Pseudomonas aeruginosa; Iran; VIM-1; systematic review.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Flowchart of study selection process
Figure 2
Figure 2
Forest plot illustrating weighted relative frequency using random effects model for assessing overall prevalence of positive VIM-1 Pseudomonas aeruginosa samples in Iranian hospitalized patients
Figure 3
Figure 3
Begg's funnel plots (with pseudo 95% confidence intervals) of the relative frequencies (RFs) versus the standard errors of the Framingham risks in studies that evaluated the positive VIM-1 in Pseudomonas aeruginosa samples in Iranian hospitalized patients
See this image and copyright information in PMC

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References

    1. Tsakris A, Poulou A, Kristo I, Pittaras T, Spanakis N, Pournaras S, et al. Large dissemination of VIM-2-metallo-beta-lactamase-producing Pseudomonas aeruginosa strains causing health care-associated community-onset infections. J Clin Microbiol. 2009;47:3524–9. - PMC - PubMed
    1. Tam VH, Chang KT, LaRocco MT, Schilling AN, McCauley SK, Poole K, et al. Prevalence, mechanisms, and risk factors of carbapenem resistance in bloodstream isolates of Pseudomonas aeruginosa. Diagn Microbiol Infect Dis. 2007;58:309–14. - PubMed
    1. Lee MF, Peng CF, Hsu HJ, Chen YH. Molecular characterisation of the metallo-beta-lactamase genes in imipenem-resistant Gram-negative bacteria from a university hospital in southern Taiwan. Int J Antimicrob Agents. 2008;32:475–80. - PubMed
    1. Jacoby GA, Munoz-Price LS. The new beta-lactamases. N Engl J Med. 2005;352:380–91. - PubMed
    1. Walsh TR. Clinically significant carbapenemases: An update. Curr Opin Infect Dis. 2008;21:367–71. - PubMed

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