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Review
. 2014:2014:408047.
doi: 10.1155/2014/408047. Epub 2014 Sep 16.

Levels of soluble E-cadherin in breast, gastric, and colorectal cancers

Ombretta Repetto  1 , Paolo De Paoli  2 , Valli De Re  1 , Vincenzo Canzonieri  3 , Renato Cannizzaro  4
Affiliations
Review

Levels of soluble E-cadherin in breast, gastric, and colorectal cancers

Ombretta Repetto et al. Biomed Res Int. 2014.

Abstract

Soluble E-cadherin is a 80 kDa protein fragment coming from the proteolytic cleavage of the extracellular domain of the full length epithelial cadherin, a molecule involved in cell adhesion/polarity and tissue morphogenesis. In comparison with normal epithelia, cancer cells show a decreased cadherin-mediated intercellular adhesion, and sE-cad levels normally increase in body fluids (blood and urine). This review focuses on soluble E-cadherin in sera of patients affected by three solid cancers (breast, gastric, and colorectal cancers) and how its levels correlate or not with some cancer parameters (e.g., dimension, progression, and localisation). We will describe the main proteomics approaches adopted to measure sE-cad both in vivo and in vitro and the most important findings about its behaviour in cancer dynamics.

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