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Comment
. 2014 Dec 22;31(6):669-70.
doi: 10.1016/j.devcel.2014.12.005.

Unleashing mesenchymal chemotaxis

Rocío Aguilar-Cuenca  1 , Miguel Vicente-Manzanares  2
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Unleashing mesenchymal chemotaxis

Rocío Aguilar-Cuenca et al. Dev Cell. .
Free article

Abstract

In this issue of Developmental Cell, Asokan and colleagues (2014) report that the phospholipase Cγ (PLCγ)-diacyl glycerol (DAG) protein kinase Cα (PKCα) signaling axis inhibits actomyosin bundling. This preferentially occurs at the leading edge of chemotactic mesenchymal cells via noncanonical phosphorylation of the regulatory light chain (RLC) of nonmuscle myosin II.

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