Senescence helps regeneration
- PMID: 25535913
- DOI: 10.1016/j.devcel.2014.12.007
Senescence helps regeneration
Abstract
Cellular senescence is a response to damage that involves inflammation and extracellular matrix remodeling and that resolves with the phagocytic elimination of the senescent cells. Demaria et al. (2014) in this issue of Developmental Cell demonstrate that cellular senescence plays an active and positive role during tissue regeneration.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.Dev Cell. 2014 Dec 22;31(6):722-33. doi: 10.1016/j.devcel.2014.11.012. Epub 2014 Dec 11. Dev Cell. 2014. PMID: 25499914 Free PMC article.
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