Cullins keep autophagy under control

Abstract

Autophagy removes protein aggregates, damaged organelles, and intracellular pathogens from cells and helps to recycle lipids and protein building blocks. However, regulatory mechanisms of the initial, rapid response are largely unknown. In this issue of Developmental Cell, Antonioli et al. (2014) provide mechanistic insights into autophagy induction and termination by Cullin E3 ligases.