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. 2015 Feb 7;51(11):2091-4.
doi: 10.1039/c4cc07960d.

Near infrared activation of an anticancer Pt(IV) complex by Tm-doped upconversion nanoparticles

Emmanuel Ruggiero  1 , Javier Hernández-Gil, Juan C Mareque-Rivas, Luca Salassa
Affiliations

Near infrared activation of an anticancer Pt(IV) complex by Tm-doped upconversion nanoparticles

Emmanuel Ruggiero et al. Chem Commun (Camb). .

Erratum in

Abstract

The Pt(IV) complex cis,cis,trans-[Pt(NH3)2(Cl)2(O2CCH2CH2CO2H)2] is photoactivated by near infrared light (980 nm) using NaYF4:Yb(3+)/Tm(3+)@NaYF4 core-shell upconversion nanoparticles. Coupling of this cisplatin precursor with the biocompatible PEGylated phospholipid DSPE-PEG(2000)-NH2 affords a valuable approach to decorate the surface of the nanoparticles, providing novel photoactivatable nanomaterials capable of releasing Pt(II) species upon NIR light excitation.

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