Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Sep:19:377-88.

Allelic polymorphism of DNA repair gene XRCC1 in patients with thyroid cancer who were exposed to ionizing radiation as a result of the Chornobyl accident

[Article in English, Ukrainian]
V M Shkarupa  1 , S O Henyk-Berezovska  2 , L V Neumerzhytska  1 , S V Klymenko  1
Affiliations
  • PMID: 25536575

Allelic polymorphism of DNA repair gene XRCC1 in patients with thyroid cancer who were exposed to ionizing radiation as a result of the Chornobyl accident

[Article in English, Ukrainian]
V M Shkarupa et al. Probl Radiac Med Radiobiol. 2014 Sep.

Abstract
in English, Ukrainian

Objective - to determine and compare the features of DNA repair gene XRCC1 Arg399Gln polymorphisms in patients with thyroid cancer (TC), who were exposed to ionizing radiation as a result of the Chornobyl disaster, and in patients without exposure to ionizing radiation in history. Materials and methods. Determination of gene XRCC1 Arg399Gln polymorphisms was performed by polymerase chain reaction (PCR) in 102 patients with thyroid cancer: 38 people, who were exposed to ionizing radiation due to Chornobyl disaster (clean-up workers, evacuees and residents from controlled areas contaminated with radionuclides) and 64 individuals without exposure to ionizing radiation in anamnesis. The literature data on control groups of populations of Russia and Belarus were used for comparison of the data on spontaneous and radiation-associated thyroid cancer and calculation of allele frequencies differences and risk of cancer pathology. Results. Frequency of minor allele Arg399Gln XRCC1 gene and homozygous carriers of this allele in patients with thyroid cancer, who were exposed to ionizing radiation due to Chornobyl disaster was significantly higher than in patients without exposure to ionizing radiation in anamnesis (0.57 and 0.37, p = 0.006 and 34.21 % and 7.81 %, p = 0.001, respectively). Comparing to the literature data on XRCC1 Arg399Gln polymorphisms in radiation-exposed individuals without cancer pathology, the risk of thyroid cancer in homozygous minor allele XRCC1 Gln399Gln carriers, who were exposed to ionizing radiation was significantly increased: OR = 4.14, p = 0.001 (CI95 % 1.72-9.93). Conclusions. The carrying of homozygous minor allele Gln399Gln of DNA repair gene XRCC1 is a risk factor for thyroid cancer under the influence of ionizing radiation in research group of Ukrainian population.

Metoju roboty bulo vyznachyty ta porivnjaty osoblyvosti polimorfizmu gena reparacii' XRCC1 Arg399Gln u hvoryh na rak shhytopodibnoi' zalozy (RShhZ), jaki zaznaly dii' ionizujuchoi' radiacii' vnaslidok avarii' na Chornobyl'skij AES, ta u hvoryh bez vplyvu ionizujuchogo vyprominennja v anamnezi. Materialy i metody. Vyznachennja polimorfizmu gena XRCC1 Arg399Gln provodylos' shljahom PLR u 102 hvoryh na RShhZ: 38 osib, jaki zaznaly dii' ionizujuchoi' radiacii' vnaslidok avarii' na Chornobyl'skij AES (ULNA, evakujovani ta meshkanci kontrol'ovanyh terytorij, zabrudnenyh radionuklidamy) ta 64 osoby bez vplyvu ionizujuchogo vyprominennja v anamnezi. Dlja porivnjannja otrymanyh danyh shhodo spontannogo ta radiacijno-asocijovanogo RShhZ ta rozrahunkiv vidminnostej chastot alelej i ryzyku vynyknennja onkopatologii' vykorystovuvaly dani literatury shhodo kontrol'nyh grup populjacij Rosijs'koi' Federacii' ta Bjelarusi. Rezul'taty. Chastota minornogo alelju gena XRCC1 Arg399Gln ta gomozygotnyh nosii'v c'ogo alelju u hvoryh na RShhZ, jaki zaznaly dii' ionizujuchoi' radiacii' vnaslidok avarii' na Chornobyl'skij AES dostovirno bil'sha, nizh u hvoryh bez vplyvu ionizujuchogo vyprominennja v anamnezi (0,57 i 0,37, r = 0,006 ta 34,21 i 7,81 % r = 0,001, vidpovidno). Pry porivnjanni z danymy literatury shhodo polimorfizmu XRCC1 Arg399Gln u radiacijno-eksponovanyh osib bez onkopatologii', ryzyk rozvytku RShhZ u gomozygotnyh nosii'v minornogo alelju XRCC1 Gln399Gln u osib, jaki zaznaly vplyvu ionizujuchogo vyprominennja, vyjavyvsja dostovirno pidvyshhenym: OR = 4,14, p = 0,001 (CI 95 % 1,72–9,93). Vysnovky. Nosijstvo gomozygotnyh minornyh alelej gena reparacii' DNK XRCC1 Gln399Gln je faktorom ryzyku rozvytku RShhZ za umov vplyvu IV v doslidzhenij grupi ukrai'ns'koi' populjacii'.

Keywords: Chornobyl disaster; XRCC1 gene polymorphisms; thyroid cancer.

PubMed Disclaimer

LinkOut - more resources