Reply to Pembrey et al: 'ZNF277 microdeletions, specific language impairment and the meiotic mismatch methylation (3M) hypothesis'

Fabiola Ceroni¹, Nuala H Simpson¹, Clyde Francks², Gillian Baird³, Gina Conti-Ramsden⁴, Ann Clark⁵, Patrick F Bolton⁶, Elizabeth R Hennessy⁷, Peter Donnelly¹, David R Bentley⁸, Hilary Martin¹; IMGSAC; SLI Consortium; WGS500 Consortium; Jeremy Parr⁹, Alistair T Pagnamenta¹⁰, Elena Maestrini¹¹, Elena Bacchelli¹¹, Simon E Fisher², Dianne F Newbury¹

Affiliations

¹ Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
² 1] Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands [2] Donders Institute for Brain, Cognition & Behaviour, Nijmegen, The Netherlands.
³ Guy's & St Thomas NHS Foundation Trust, Newcomen Children's Neurosciences Centre, St Thomas' Hospital, London, UK.
⁴ School of Psychological Sciences, The University of Manchester, Manchester, UK.
⁵ Speech and Hearing Sciences, Queen Margaret University, Edinburgh, UK.
⁶ Departments of Child & Adolescent Psychiatry & Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Kings College London, London, UK.
⁷ University Child Health and DMDE, University of Aberdeen, Aberdeen, UK.
⁸ Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Essex, UK.
⁹ Institute of Neuroscience and Health and Society, Newcastle University, Newcastle upon Tyne, UK.
¹⁰ 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK [2] NIHR Biomedical Research Centre, Oxford and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
¹¹ Dipartimento di Farmacia e Biotecnologie, University of Bologna, Bologna, Italy.

PMID: 25537359
PMCID: PMC4538219
DOI: 10.1038/ejhg.2014.275

Comment

Reply to Pembrey et al: 'ZNF277 microdeletions, specific language impairment and the meiotic mismatch methylation (3M) hypothesis'

Fabiola Ceroni et al. Eur J Hum Genet. 2015 Sep.

. 2015 Sep;23(9):1113-5.

doi: 10.1038/ejhg.2014.275. Epub 2014 Dec 24.

Authors

Affiliations

¹ Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
² 1] Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands [2] Donders Institute for Brain, Cognition & Behaviour, Nijmegen, The Netherlands.
³ Guy's & St Thomas NHS Foundation Trust, Newcomen Children's Neurosciences Centre, St Thomas' Hospital, London, UK.
⁴ School of Psychological Sciences, The University of Manchester, Manchester, UK.
⁵ Speech and Hearing Sciences, Queen Margaret University, Edinburgh, UK.
⁶ Departments of Child & Adolescent Psychiatry & Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Kings College London, London, UK.
⁷ University Child Health and DMDE, University of Aberdeen, Aberdeen, UK.
⁸ Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Essex, UK.
⁹ Institute of Neuroscience and Health and Society, Newcastle University, Newcastle upon Tyne, UK.
¹⁰ 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK [2] NIHR Biomedical Research Centre, Oxford and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
¹¹ Dipartimento di Farmacia e Biotecnologie, University of Bologna, Bologna, Italy.

PMID: 25537359
PMCID: PMC4538219
DOI: 10.1038/ejhg.2014.275

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Comment on

Homozygous microdeletion of exon 5 in ZNF277 in a girl with specific language impairment.
Ceroni F, Simpson NH, Francks C, Baird G, Conti-Ramsden G, Clark A, Bolton PF, Hennessy ER, Donnelly P, Bentley DR, Martin H; IMGSAC; SLI Consortium; WGS500 Consortium; Parr J, Pagnamenta AT, Maestrini E, Bacchelli E, Fisher SE, Newbury DF. Ceroni F, et al. Eur J Hum Genet. 2014 Oct;22(10):1165-71. doi: 10.1038/ejhg.2014.4. Epub 2014 Feb 12. Eur J Hum Genet. 2014. PMID: 24518835 Free PMC article.
ZNF277 microdeletions, specific language impairment and the meiotic mismatch methylation (3M) hypothesis.
Pembrey M, Golding J, Connelly J. Pembrey M, et al. Eur J Hum Genet. 2015 Sep;23(9):1113. doi: 10.1038/ejhg.2014.262. Epub 2014 Dec 24. Eur J Hum Genet. 2015. PMID: 25537358 Free PMC article. No abstract available.

References

1. Ceroni F, Simpson NH, Francks C et al: Homozygous microdeletion of exon 5 in ZNF277 in a girl with specific language impairment. Eur J Hum Genet 2014; 22: 1165–1171. - PMC - PubMed
1. Golding J, Steer C, Pembrey M: Parental and grandparental ages in the autistic spectrum disorders: a birth cohort study. PLoS One 2010; 5: e9939. - PMC - PubMed
1. Zhou FC: DNA methylation program during development. Front Biol 2012; 7: 485–494. - PMC - PubMed

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Reply to Pembrey et al: 'ZNF277 microdeletions, specific language impairment and the meiotic mismatch methylation (3M) hypothesis'

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Reply to Pembrey et al: 'ZNF277 microdeletions, specific language impairment and the meiotic mismatch methylation (3M) hypothesis'

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