Role of Corticotropin-releasing Factor in Gastrointestinal Permeability

Abstract

The interface between the intestinal lumen and the mucosa is the location where the majority of ingested immunogenic particles face the scrutiny of the vast gastrointestinal immune system. Upon regular physiological conditions, the intestinal microflora and the epithelial barrier are well prepared to process daily a huge amount of food-derived antigens and non-immunogenic particles. Similarly, they are ready to prevent environmental toxins and microbial antigens to penetrate further and interact with the mucosal-associated immune system. These functions promote the development of proper immune responses and oral tolerance and prevent disease and inflammation. Brain-gut axis structures participate in the processing and execution of response signals to external and internal stimuli. The brain-gut axis integrates local and distant regulatory networks and supersystems that serve key housekeeping physiological functions including the balanced functioning of the intestinal barrier. Disturbance of the brain-gut axis may induce intestinal barrier dysfunction, increasing the risk of uncontrolled immunological reactions, which may indeed trigger transient mucosal inflammation and gut disease. There is a large body of evidence indicating that stress, through the brain-gut axis, may cause intestinal barrier dysfunction, mainly via the systemic and peripheral release of corticotropin-releasing factor. In this review, we describe the role of stress and corticotropin-releasing factor in the regulation of gastrointestinal permeability, and discuss the link to both health and pathological conditions.

Keywords: Corticotropin-releasing factor; Inflammation; Permeability; Stress.

Figure.

Corticotropin-releasing factor actions on gastrointestinal permeability under stress conditions. JAM-A-B-C, junctional adhesion molecule A-B-C; SP, substance P; ACh, acetylcholine; MBP, major basic protein; CRF, corticotropin- releasing factor; CRF₁, CRF receptor 1; CRF₂, CRF receptor 2; PAR2, protease activated receptor 2.