Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Nov;55(6):508-11.
doi: 10.4103/0300-1652.144711.

Comparison of microalbuminuria among treatment naïve HIV sero-positive and negative adult clients in Faith Alive Foundation Hospital, Jos

Dalili Mohammed Shabbal  1 , Mustapha Abubakar Jamda  2 , Ibrahim Tijjani Dalhatu  3 , Muhammad Bashir Abdulrahman  4 , Chris Isichei  5
Affiliations

Comparison of microalbuminuria among treatment naïve HIV sero-positive and negative adult clients in Faith Alive Foundation Hospital, Jos

Dalili Mohammed Shabbal et al. Niger Med J. 2014 Nov.

Abstract

Background: This study is to determine microalbuminuria in human immunodeficiency virus (HIV) infected patients before commencement of highly active anti-retroviral treatment (HAART).

Patients and methods: Consecutive patients with the HIV infection seen in the HIV counselling and testing (HCT) unit of the Faith Alive Foundation Hospital, Jos, and a similar group of healthy uninfected patients were evaluated for renal disease: Urinary albumin and urinary creatinine were analysed.

Results: Of the 200 patients with HIV infection and 100 uninfected controls studied, increased urinary albumin excretion (UAE) was present in 39 (19.5%) of the subjects and 5.0 (5.0%) of controls. The difference between the mean values for the UAE for both subjects and controls [182.3 ± 54.3 and 163.9 ± 39.3 mg/l, respectively (P = 0.006)] was statistically significant. On the other hand the urinary creatinine for both the subjects and controls [11.7 ± 5.2 and 12.0 ± 4.8 mmol/L, respectively (P = 0.6)] was not statistically significant. The difference between the mean urinary albumin/creatinine ratio (UACR) for both subjects and controls [1.8 ± 1.2 mg/mmol and 1.4 ± 0.4 mg/mmol respectively (P = 0.001)] was statistically significant.

Conclusion/recommendation: Increase UAE is a common complication of HIV infection due to a number of factors other than HAART. Early screening for renal disease using microalbuminuria is very useful since the use of medications such as angiotensin converting enzyme inhibitors, which could help reverse progression to end-stage renal disease.

Keywords: HIV infection; microalbuminuria; renal disease risk; urinary albumin and creatinine.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Brooks GF, Butel SG, Morse AS. AIDS and Lentiviruses. In: Jawetz, Melnick, Adelberg, editors. Medical Microbiology. 23rd ed. San Francisco: McGrew-Hills; 2004. p. 605.
    1. Fabian J, Katz L, Gerntholtz T, Goetsch S, Naicka S. CKD in HIV infections. Am J Kidney Dis. 1997;29:514–25. - PubMed
    1. National AIDS/HIV/STD Control Programme Federal Ministry of Health and Social (Services) Technical reports. 1997 1999, 2000, 2003.
    1. Agaba EI, Agaba PA, Sirisena ND, Anteyi EA, Idoko JA. Renal disease in the acquired immunodeficiency syndrome in north central Nigeria. Niger J Med. 2003;12:120–5. - PubMed
    1. Pardo V, Meneses R, Ossa L, Jaffe DJ, Strauss J, Roth D, et al. AIDS-related glomerulopathy: Occurrence in specific risk groups. Kidney Int. 1987;31:1167–73. - PubMed