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. 2014 Dec;18(12):783-8.
doi: 10.4103/0972-5229.146305.

Alteco endotoxin hemoadsorption in Gram-negative septic shock patients

Hoi Ping Shum  1 , Yuk Wah Leung  1 , Sin Man Lam  1 , King Chung Chan  1 , Wing Wa Yan  1
Affiliations

Alteco endotoxin hemoadsorption in Gram-negative septic shock patients

Hoi Ping Shum et al. Indian J Crit Care Med. 2014 Dec.

Abstract

Background and aims: Severe sepsis and septic shock are common causes of mortality and morbidity in an intensive care unit setting. Endotoxin, derived from the outer membranes of Gram-negative bacteria, is considered a major factor in the pathogenesis of sepsis. This study investigated the effect of Alteco endotoxin hemoadsorption device on Gram-negative septic shock patients.

Materials and methods: An open, controlled, prospective, randomized, single-center trial was conducted between February 2010 and June 2012. Patients with septic shock due to intra-abdominal sepsis were randomized to either conventional therapy (n = 8) or conventional therapy plus two 2-hourly sessions of Alteco endotoxin hemoadsorption (n = 7). Primary endpoint was the Sequential Organ Failure Assessment (SOFA) score changes from 0 to 72 h. Secondary end points included vasopressor requirement, PaO2/FiO2 ratio (PFR), length of stay (LOS), and 28-day mortality.

Results: This study was terminated early as interim analysis showed a low probability of significant findings. No significant difference was noted between the two groups with respect to change in SOFA score, vasopressor score, PFR, LOS, and 28-day mortality. Side-effect was minimal.

Conclusions: We could not identify any clinical benefit on the addition of Alteco endotoxin hemoadsorption to conventional therapy in patients who suffered from intra-abdominal sepsis with shock. The side effect profile of this novel device was acceptable.

Keywords: Endotoxins; hemoadsorption; outcome; septic shock.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Randomization and follow-up of study patients
See this image and copyright information in PMC

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