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. 2014 Sep;13(3):149-53.
doi: 10.4103/1450-1147.144812.

Comparison of the Relative Renal Function Calculated with 99mTc-Diethylenetriaminepentaacetic Acid and 99mTc-Dimercaptosuccinic Acid in Children

Tanju Çelik  1 , Hülya Yalçin  2 , Emel Ceylan Günay  3 , Aynur Özen  4 , Cahit Özer  5
Affiliations

Comparison of the Relative Renal Function Calculated with 99mTc-Diethylenetriaminepentaacetic Acid and 99mTc-Dimercaptosuccinic Acid in Children

Tanju Çelik et al. World J Nucl Med. 2014 Sep.

Abstract

The aim was to compare the relative renal functions measured with technetium-99m dimercaptosuccinic acid (99mTc-DMSA) and technetium-99m diethylenetriaminepentaacetic acid (99mTc-DTPA) in children with renal diseases. Relative renal function of 128 children who applied to three hospitals from 2009 to 2011 were analyzed retrospectively. The mean value measured with 99mTc-DTPA and 99mTc-DMSA were 51.58 ± 14.95 and 51.96 ± 14.99 for the right kidney, 47.87 ± 15.27 and 47.94 ± 15.17 for the left kidney, respectively. A significant positive correlation was found between the relative renal functions (r = 0.963, P < 0.001). In Bland-Altman plots, the mean difference between two methods was 0.7 and the correlation limits were between 10.1 and-10.8. As a result, although 99mTc-DMSA is accepted as the most reliable method for the determination of relative renal function, 99mTc-DTPA can be another choice for the calculation of relative renal function without a complementary DMSA scan particularly in pediatric patients who require renogram curve and GFR calculations.

Keywords: Child; relative renal function; technetium-99m diethylenetriaminepentaacetic acid; technetium-99m dimercaptosuccinic acid.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Bland-Altman plot of dimercaptosuccinic acid and diethylenetriaminepentaacetic acid for right kidney
Figure 2
Figure 2
Bland-Altman plot of dimercaptosuccinic acid and diethylenetriaminepentaacetic acid for left kidney
See this image and copyright information in PMC

References

    1. Moran JK. Technetium-99m-EC and other potential new agents in renal nuclear medicine. Semin Nucl Med. 1999;29:91–101. - PubMed
    1. Taylor A, Jr, Lallone R. Differential renal function in unilateral renal injury: Possible effects of radiopharmaceutical choice. J Nucl Med. 1985;26:77–80. - PubMed
    1. Ardela Díaz E, Miguel Martínez B, Gutiérrez Dueñas JM, Díez Pascual R, García Arcal D, Domínguez Vallejo FJ. Comparative study of differential renal function by DMSA and MAG-3 in congenital unilateral uropathies. Cir Pediatr. 2002;15:118–21. - PubMed
    1. Kawashima A, Sandler CM, Goldman SM. Current roles and controversies in the imaging evaluation of acute renal infection. World J Urol. 1998;16:9–17. - PubMed
    1. Piepsz A. Cortical scintigraphy and urinary tract infection in children. Nephrol Dial Transplant. 2002;17:560–2. - PubMed