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Review
. 2014 Dec 9:5:480.
doi: 10.3389/fphys.2014.00480. eCollection 2014.

Hormonal regulation of the hypothalamic melanocortin system

Jung D Kim  1 , Stephanie Leyva  1 , Sabrina Diano  2
Affiliations
Review

Hormonal regulation of the hypothalamic melanocortin system

Jung D Kim et al. Front Physiol. .

Abstract

Regulation of energy homeostasis is fundamental for life. In animal species and humans, the Central Nervous System (CNS) plays a critical role in such regulation by integrating peripheral signals and modulating behavior and the activity of peripheral organs. A precise interplay between CNS and peripheral signals is necessary for the regulation of food intake and energy expenditure in the maintenance of energy balance. Within the CNS, the hypothalamus is a critical center for monitoring, processing and responding to peripheral signals, including hormones such as ghrelin, leptin, and insulin. Once in the brain, peripheral signals regulate neuronal systems involved in the modulation of energy homeostasis. The main hypothalamic neuronal circuit in the regulation of energy metabolism is the melanocortin system. This review will give a summary of the most recent discoveries on the hormonal regulation of the hypothalamic melanocortin system in the control of energy homeostasis.

Keywords: agouti-related peptide (AgRP); arcuate nucleus; hormones; hypothalamic melanocortin system; neuropeptide Y (NPY); obesity; pro-opiomelanocortin (POMC).

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References

    1. Andrews Z. B., Liu Z. W., Walllingford N., Erion D. M., Borok E., Friedman J. M., et al. . (2008). UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 454, 846–851. 10.1038/nature07181 - DOI - PMC - PubMed
    1. Aponte Y., Atasoy D., Sternson S. M. (2011). AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training. Nat. Neurosci. 14, 351–355. 10.1038/nn.2739 - DOI - PMC - PubMed
    1. Atasoy D., Betley J. N., Su H. H., Sternson S. M. (2012). Deconstruction of a neural circuit for hunger. Nature 488, 172–177. 10.1038/nature11270 - DOI - PMC - PubMed
    1. Bagdade J. D., Bierman E. L., Porte D., Jr. (1967). The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. J. Clin. Invest. 46, 1549–1557. 10.1172/JCI105646 - DOI - PMC - PubMed
    1. Balthasar N., Coppari R., Mcminn J., Liu S. M., Lee C. E., Tang V., et al. . (2004). Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42, 983–991. 10.1016/j.neuron.2004.06.004 - DOI - PubMed

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