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Case Reports
. 2014 Oct;19(10):1009-11.

Vasculitis and long standing ankylosing spondylitis in a patient with familial Mediterranean fever

Ali Taylan  1 , Yasar Yildiz  2 , Ismail Sari  2 , Guliz Ozkok  3
Affiliations
Case Reports

Vasculitis and long standing ankylosing spondylitis in a patient with familial Mediterranean fever

Ali Taylan et al. J Res Med Sci. 2014 Oct.

Abstract

Coexistence of familial Mediterranean fever (FMF) and other inflammatory disorders has been frequently reported, but no specific underlying factor has been identified. We report a patient with FMF who is presented with long-standing ankylosing spondylitis (AS) and cutaneous leukocytoklastic vasculitis (LV) of the lower limbs. It is the first report on combination of FMF with AS and LV. The Mediterranean Fever (MEFV) gene mutation of heterozygote (R202Q/R726A) and HLA-B27 are detected in this case, and are believed to form genetic susceptibility to LV.

Keywords: Ankylosing spondylitis; familial Mediterranean fever; leukocytoklastic vasculitis; vasculitis.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
(a) Stage IV sacroiliitis. (b) Apophyseal joints involvement without vertebral squaring and bamboo spine
Figure 2
Figure 2
Microscopy of skin lesions suggestive of leukocytoklastic vasculitis: Fibrin deposits, nuclear debris, and neutrophils infiltrating capillary wall (hematoxylin and eosin (H and E), 200)
See this image and copyright information in PMC

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