Copper-mediated trifluoromethylation using phenyl trifluoromethyl sulfoxide
- PMID: 25541645
- DOI: 10.1021/ol5034018
Copper-mediated trifluoromethylation using phenyl trifluoromethyl sulfoxide
Abstract
A new method for the generation of trifluoromethylcopper ("CuCF3") species from readily available phenyl trifluoromethyl sulfoxide has been developed. The "CuCF3" reagent can be applied in efficient trifluoromethylations of aryl iodides and activated aryl bromides in the absence of additional ligands. Furthermore, the "CuCF3" species can also undergo oxidative cross-coupling with terminal alkynes and arylboronic acids.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources