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. 2015 Jan 16;17(2):298-301.
doi: 10.1021/ol5034018. Epub 2014 Dec 26.

Copper-mediated trifluoromethylation using phenyl trifluoromethyl sulfoxide

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Copper-mediated trifluoromethylation using phenyl trifluoromethyl sulfoxide

Xinjin Li et al. Org Lett. .

Abstract

A new method for the generation of trifluoromethylcopper ("CuCF3") species from readily available phenyl trifluoromethyl sulfoxide has been developed. The "CuCF3" reagent can be applied in efficient trifluoromethylations of aryl iodides and activated aryl bromides in the absence of additional ligands. Furthermore, the "CuCF3" species can also undergo oxidative cross-coupling with terminal alkynes and arylboronic acids.

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