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. 1989 Jul 31;102(2-3):303-8.
doi: 10.1016/0304-3940(89)90096-7.

Effects of metaphit on phencyclidine and serotonin2 receptors

T Nabeshima  1 , K Tohyama, A Noda, Y Maeda, M Hiramatsu, S M Harrer, T Kameyama, H Furukawa, A E Jacobson, K C Rice
Affiliations

Effects of metaphit on phencyclidine and serotonin2 receptors

T Nabeshima et al. Neurosci Lett. .

Abstract

We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin2 (5-HT2) receptors, and also whether metaphit decreases the capacity of 5-HT2 receptors. Metaphit (1 mumol/rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT2 receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT2 receptors may have very similar binding sites.

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