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. 1989 Nov;4(11):1281-4.

A newly isolated avian sarcoma virus, ASV-1, carries the crk oncogene

H Tsuchie  1 , C H Chang, M Yoshida, P K Vogt
Affiliations
  • PMID: 2554234

A newly isolated avian sarcoma virus, ASV-1, carries the crk oncogene

H Tsuchie et al. Oncogene. 1989 Nov.

Abstract

Avian sarcoma virus 1 (ASV-1) was isolated from a spontaneous sarcoma of an adult chicken. It is a replication-defective virus that induces fibrosarcomas in young chickens and oncogenic transformation in cultured chick embryo fibroblasts. The ASV-1 genome has been cloned in the lambda gt WES.lambda B vector from closed circular viral DNA extracted from infected cells. The nucleotide sequence of the oncogene insert in the ASV-1 genome has been determined. It is virtually identical to the sequence of the oncogene crk recently discovered in the avian sarcoma virus CT10. ASV-1 and CT10 are two independent retrovirus isolates carrying the crk oncogene.

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