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Comparative Study
. 1989 Oct;86(20):7711-5.
doi: 10.1073/pnas.86.20.7711.

v-maf, a viral oncogene that encodes a "leucine zipper" motif

M Nishizawa  1 , K Kataoka, N Goto, K T Fujiwara, S Kawai
Affiliations
Comparative Study

v-maf, a viral oncogene that encodes a "leucine zipper" motif

M Nishizawa et al. Proc Natl Acad Sci U S A. 1989 Oct.

Abstract

We have molecularly cloned the provirus of the avian musculoaponeurotic fibrosarcoma virus AS42. Nucleotide sequence analysis of a biologically active clone of AS42 showed that this virus encodes a viral oncogene, maf. The deduced amino acid sequence of the v-maf gene product contains a "leucine zipper" motif similar to that found in a number of DNA binding proteins, including the gene products of the fos, jun, and myc oncogenes. However, unlike these oncogenes, the cellular maf gene was not transcriptionally activated by growth stimulation of cultured cells.

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References

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    1. Nature. 1988 Dec 15;336(6200):646-51 - PubMed
    1. Genes Dev. 1988 Jul;2(7):786-800 - PubMed
    1. Cell. 1989 Feb 10;56(3):507-16 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Mar;86(5):1500-3 - PubMed

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