Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014:2014:468653.
doi: 10.1155/2014/468653. Epub 2014 Dec 3.

Macular findings obtained by spectral domain optical coherence tomography in retinopathy of prematurity

Muhammet Kazim Erol  1 , Ozdemir Ozdemir  2 , Deniz Turgut Coban  1 , Ahmet Burak Bilgin  3 , Berna Dogan  1 , Esin Sogutlu Sari  4 , Devrim Toslak  1
Affiliations

Macular findings obtained by spectral domain optical coherence tomography in retinopathy of prematurity

Muhammet Kazim Erol et al. J Ophthalmol. 2014.

Abstract

Purpose. To examine the macular findings obtained with spectral domain optical coherence tomography (SD OCT) in infants with retinopathy of prematurity (ROP). Materials and Methods. The macular SD OCT images of 190 premature infants were analyzed. Data regarding central foveal thickness (CFT), cystoid macular edema (CME), and cyst grading were compared. The relationships of CFT with gestational age and birth weight were investigated. Results. The results were obtained from 358 eyes of 179 infants (81 females and 98 males) of a mean gestational age of 30.9 ± 2.7 weeks and a mean birth weight of 1609 ± 477 g. ROP was diagnosed in 126 eyes and CME in 139 eyes. A significantly greater percentage of eyes with ROP were found to have CME (54%) compared to eyes without ROP (31%; P = 0.001). The incidence of CME was 46.3% for stage 1 ROP, 57.1% for stage 2, and 87.5% for stage 3. There was a weakly inverse correlation between CFT, gestational age, and birth weight (P = 0.025, r = -0.227; P = 0.002, r = -0.182, resp., Spearman correlation test). Conclusions. High-quality SD OCT images can be obtained from premature infants using the iVue system. Severity and frequency of CME in premature infants increase as stage of ROP increases.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Examples of OCT images that demonstrate grade of cystoid macular edema. (a) Patient with no cystoid macular edema. (b) Patient with one or more cysts with no changes in the foveal contour. (c) One or more cysts with changes in the foveal contour.
Figure 2
Figure 2
Comparisons of mean central foveal thickness (CFT) between the eyes with and without ROP. (ROP: retinopathy of prematurity, SD: standard deviation, and P: 0.001, Mann-Whitney U test).
Figure 3
Figure 3
Comparisons of cystoid macular edema grading in eyes according to stage of ROP. (ROP: retinopathy of prematurity, P: 0.001 chi-square test).
Figure 4
Figure 4
(a) OCT image of a patient with cystoid macular edema at 39-week postmenstrual age and (b) after resolution of cystoid macular edema six weeks later.
Figure 5
Figure 5
(a) OCT image of a premature infant with type 1 ROP (zone 2 stage 3 with plus disease) before intravitreal ranibizumab treatment and (b) two months after intravitreal ranibizumab treatment.
Figure 6
Figure 6
(a) OCT image of a premature infant with type 1 ROP (zone 2 stage 3 with plus disease) before intravitreal ranibizumab treatment and (b) one week after intravitreal ranibizumab treatment.
Figure 7
Figure 7
The correlation between central foveal thickness and gestational age (P = 0.025, r = −0.227) (Spearman correlation test).
Figure 8
Figure 8
The correlation between central foveal thickness and birth weight (P = 0.002, r = −0.182) (Spearman correlation test).
See this image and copyright information in PMC

References

    1. Dobson V., Quinn G. E., Summers C. G., Hardy R. J., Tung B. Visual acuity at 10 years in cryotherapy for retinopathy of prematurity (CRYO-ROP) study eyes: effect of retinal residua of retinopathy of prematurity. Archives of Ophthalmology. 2006;124(2):199–202. doi: 10.1001/archopht.124.2.199. - DOI - PubMed
    1. Early Treatment for Retinopathy of Prematurity Cooperative Group, Good W. V., Hardy R. J., Dobson V., Palmer E. A., Phelps D. L., Tung B., Redford M. Final visual acuity results in the early treatment for retinopathy of prematurity study. Archives of Ophthalmology. 2010;128(6):663–671. doi: 10.1001/archophthalmol.2010.72. - DOI - PMC - PubMed
    1. Fierson W. M., Palmer E. A., Biglan A. W., Flynn J. T., Petersen R. A., Phelps D. L. Retinopathy of prematurity guidelines. Pediatrics. 1998;101(6, article 1093) - PubMed
    1. International Committee for the Classification of Retinopathy of Prematurity The international classification of retinopathy of prematurity revisited. Archives of Ophthalmology. 2005;123(7):991–999. - PubMed
    1. Wallace D. K., Quinn G. E., Freedman S. F., Chiang M. F. Agreement among pediatric ophthalmologists in diagnosing plus and pre-plus disease in retinopathy of prematurity. Journal of AAPOS. 2008;12(4):352–356. doi: 10.1016/j.jaapos.2007.11.022. - DOI - PMC - PubMed

LinkOut - more resources