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. 2014:2014:767621.
doi: 10.1155/2014/767621. Epub 2014 Dec 2.

Follicular lymphoma presenting with leptomeningeal disease

Rubens Costa  1 , Ricardo Costa  2 , Renata Costa  3
Affiliations

Follicular lymphoma presenting with leptomeningeal disease

Rubens Costa et al. Case Rep Hematol. 2014.

Abstract

Follicular lymphoma is generally an indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Central nervous system metastasis is a very rare complication portending a very poor prognosis. We report a rare case of follicular lymphoma presenting with leptomeningeal involvement achieving a complete remission after initial therapy.

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Figures

Figure 1
Figure 1
Computerized tomography showing a presacral mass.
Figure 2
Figure 2
Computerized tomography showing a liver mass.
Figure 3
Figure 3
Spinal fluid showing atypical lymphoid cells with cytologic features consistent with follicular lymphoma.
Figure 4
Figure 4
Lymphoid cells strongly expressing CD23.
Figure 5
Figure 5
Nodular proliferation of atypical lymphoid cells composed predominantly of centrocytes with admixed scattered centroblasts.
See this image and copyright information in PMC

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