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Review
. 2014 Dec 24;8(1):1-20.
doi: 10.3390/ph8010001.

Clinical use of proteasome inhibitors in the treatment of multiple myeloma

Noah M Merin  1 , Kevin R Kelly  2
Affiliations
Review

Clinical use of proteasome inhibitors in the treatment of multiple myeloma

Noah M Merin et al. Pharmaceuticals (Basel). .

Abstract

Multiple myeloma (MM) is an incurable hematological malignancy characterized by the clonal proliferation of neoplastic plasma cells. The use of proteasome inhibitors in the treatment of MM has led to significant improvements in outcomes. This article reviews data on the use of the two approved proteasome inhibitors (bortezomib and carlfilzomib), as well as newer agents under development. Emphasis is placed on the clinical use of proteasome inhibitors, including management of side effects and combination with other agents.

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References

    1. Siegel R., Ma J., Zou Z., Jemal A. Cancer statistics, 2014. CA Cancer J. Clin. 2014;64:9–29. doi: 10.3322/caac.21208. - DOI - PubMed
    1. Siegel R., DeSantis C., Virgo K., Stein K., Mariotto A., Smith T., Cooper D., Gansler T., Lerro C., Fedewa S., et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J. Clin. 2012;62:220–241. doi: 10.3322/caac.21149. - DOI - PubMed
    1. Kumar S.K., Rajkumar S.V., Dispenzieri A., Lacy M.Q., Hayman S.R., Buadi F.K., Zeldenrust S.R., Dingli D., Russell S.J., Lust J.A., et al. Improved survival in multiple myeloma and the impact of novel therapies. Blood. 2008;111:2516–2520. doi: 10.1182/blood-2007-10-116129. - DOI - PMC - PubMed
    1. Kumar S.K., Dispenzieri A., Lacy M.Q., Gertz M.A., Buadi F.K., Pandey S., Kapoor P., Dingli D., Hayman S.R., Leung N., et al. Continued improvement in survival in multiple myeloma: Changes in early mortality and outcomes in older patients. Leukemia. 2014;28:1122–1128. doi: 10.1038/leu.2013.313. - DOI - PMC - PubMed
    1. Raje N., Singhal S., Stockerl-Goldstein K., Treon S.P., Yahalom J., Gasparetto C., Hernandez-Ilizaliturri F., Huff C.A., Kassim A., Krishnan A.Y. NCCN Guidelines Version 2.2014 Multiple Myeloma. National Comprehensive Cancer Network; Fort Washington, PA, USA: 2013.