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. 2014 Dec 23;20(1):127-34.
doi: 10.3390/molecules20010127.

Xanthones from the roots of Moutabea guianensis Aubl

Haroldo da S Ripardo Filho  1 , Luidi C Pacheco  2 , Edinaldo da S Andrade  3 , Marivaldo José C Correa  4 , Railda Neyva M Araújo  5 , Giselle Maria S P Guilhon  6 , Joyce Kelly R da Silva  7 , Lourivaldo S Santos  8
Affiliations

Xanthones from the roots of Moutabea guianensis Aubl

Haroldo da S Ripardo Filho et al. Molecules. .

Abstract

The phytochemical investigation of Moutabea guianensis roots led to the isolation of five polyoxygenated xanthones, including two new ones named moutabeone B (1,8-dihydroxy-4,5,6,7-tetramethoxyxanthone) and moutabeone C (1-hydroxy-4,5,6,7,8-pentamethoxyxanthone), along with the three known xanthones, 1,8-dihydroxy-4,6-dimethoxyxanthone, 1,8-dihydroxy-4,5,6-trimethoxyxanthone and augustin A (1,8-dihydroxy-4,6,7-trimethoxyxanthone). Structural characterization of all compounds was established on the basis of spectroscopic methods, mainly 1D and 2D nuclear magnetic resonance (NMR) and comparison with literature data. The antioxidant activity of compounds was tested through a thin layer chromatography (TLC) bioautography assay using 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH·) as detection reagent. All tested compounds were more active (DL < 0.13-0.03 µg) than Trolox (DL < 0.15 µg), used as reference standard.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Xanthones from Moutabea guianensis.
Figure 2
Figure 2
HMBC correlations (H→C) of compounds 2 and 5.
Figure 3
Figure 3
TLC plate showing the antioxidant activity by compounds (1–5) and Trolox (T). Substances along the y-axis and concentration along the x-axis.
See this image and copyright information in PMC

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