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. 2014:2014:807430.
doi: 10.1155/2014/807430. Epub 2014 Dec 8.

Multiphasic multidetector computed tomography study of a rare tracheal tumor: granular cell tumor

Tommaso Guarnieri  1 , Luciano Cardinale  1 , Gianluca Macchia  2 , Giancarlo Cortese  2 , Andrea Veltri  1
Affiliations

Multiphasic multidetector computed tomography study of a rare tracheal tumor: granular cell tumor

Tommaso Guarnieri et al. Case Rep Pulmonol. 2014.

Abstract

Our aim is to present the case report of a woman affected by tracheal granular cell tumor analysed by multiphasic contrast-enhanced multidetector CT. The tumor presents as polypoid lesion (diameter 13 mm), with smooth and well-defined margins, elevated contrast enhancement in arterial phase, and a modest release of contrast in venous phase. This pattern is quite different from the other tracheal tumours. We have performed a comprehensive review of literature to assess all cases of granular cell tumors of the trachea; only 40 cases are reported. Of these, no one focused on the contrast enhancement aspect, so our work is the first showing a specific pattern in multidetector computed tomography (MDCT) of the tracheal granular cell tumour and may help in differential diagnosis.

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Figures

Figure 1
Figure 1
64-year-old female with granular cell tumor of trachea. Axial multiphase contrast-enhanced CT (16-slice Multidetector CT, GE Medical Systems) demonstrating polypoid lesion (diameter 13 mm) (white arrows), which presents smooth and well-defined margins and occupies the left side of the tracheal lumen. This mass does not present infiltrative signs suggestive of malignancy. The lesion shows elevated contrast enhancement in arterial phase and a modest release of contrast in venous phase; this behaviour is the tomographic expression of the rich vascularity of this kind of tumor. (a) Basal: 36 HU. (b) Arterial phase: 120 HU. (c) Venous phase: 100 HU.
Figure 2
Figure 2
64-year-old female with granular cell tumor of trachea. Coronal contrast-enhanced CT scan (16-slice Multidetector CT, GE Medical Systems, venous phase) obtained at the level of the aortic arch shows an eccentrical mass (white arrow) growing in the left side of trachea, occupying half of the tracheal lumen.
Figure 3
Figure 3
64-year-old female with granular cell tumor of trachea. Shaded surface display (SSD) image of trachea that shows the impact of mass (black arrow) on trachea lumen (16-slice Multidetector CT, GE Medical Systems).
Figure 4
Figure 4
64-year-old female with granular cell tumor of trachea. (a) Virtual bronchoscopy image (16-slice Multidetector CT, GE Medical Systems) and (b) real bronchoscopy image that shows intratracheal sessile lesion (black arrows), characterized by round shape and polylobulated border, originating from left wall of middle portion of trachea and protruding into trachea lumen occupying half of its diameter.
See this image and copyright information in PMC

References

    1. Desai D. P., Maddalozzo J., Holinger L. D. Granular cell tumor of the trachea. Otolaryngology—Head and Neck Surgery. 1999;120(4):595–598. doi: 10.1053/hn.1999.v120.a84488. - DOI - PubMed
    1. Leboulanger N., Rouillon I., Papon J. F., Josset P., Roger G., Garabédian E. N. Childhood granular cell tumors: two case reports. International Journal of Pediatric Otorhinolaryngology. 2008;72(2):279–283. doi: 10.1016/j.ijporl.2007.10.021. - DOI - PubMed
    1. Joung M.-K., Lee Y. J., Chung C.-U., Lee J. E., Jung S. S., Kim S. Y., Kim J. O. A case of granular cell tumor of the trachea. The Korean Journal of Internal Medicine. 2007;22(2):101–105. doi: 10.3904/kjim.2007.22.2.101. - DOI - PMC - PubMed
    1. Yasuda M., Hanagiri T., Ichiki Y., Uramoto H., Takenoyama M., Yasumoto K. Surgical treatment of patients with stenosis of the central airway due to tracheal tumours. Asian Journal of Surgery. 2010;33(4):212–217. doi: 10.1016/S1015-9584(11)60010-9. - DOI - PubMed
    1. Ipakchi R., Zager W. H., de Baca M. E., Bloedon E., McCue P. A., Zwillenberg D. Granular cell tumor of the trachea in pregnancy: a case report and review of literature. Laryngoscope. 2004;114(1):143–147. doi: 10.1097/00005537-200401000-00026. - DOI - PubMed

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