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Randomized Controlled Trial
. 2014:2014:324307.
doi: 10.1155/2014/324307. Epub 2014 Dec 7.

Vinpocetine and pyritinol: a new model for blood rheological modulation in cerebrovascular disorders—a randomized controlled clinical study

Hayder M Alkuraishy  1 , Ali I Al-Gareeb  1 , Ali K Albuhadilly  2
Affiliations
Randomized Controlled Trial

Vinpocetine and pyritinol: a new model for blood rheological modulation in cerebrovascular disorders—a randomized controlled clinical study

Hayder M Alkuraishy et al. Biomed Res Int. 2014.

Abstract

Blood and plasma viscosity are the major factors affecting blood flow and normal circulation. Whole blood viscosity is mainly affected by plasma viscosity, red blood cell deformability/aggregation and hematocrit, and other physiological factors. Thirty patients (twenty males + ten females) with age range 50-65 years, normotensive with history of cerebrovascular disorders, were selected according to the American Heart Stroke Association. Blood viscosity and other rheological parameters were measured after two-day abstinence from any medications. Dual effects of vinpocetine and pyritinol exhibit significant effects on all hemorheological parameters (P < 0.05), especially on low shear whole blood viscosity (P < 0.01), but they produced insignificant effects on total serum protein and high shear whole blood viscosity (P > 0.05). Therefore, joint effects of vinpocetine and pyritinol improve blood and plasma viscosity in patients with cerebrovascular disorders.

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Figures

Figure 1
Figure 1
Gender differences in RBS rigidity index (RRI) in responses to the vinpocetine and/or pyritinol.
See this image and copyright information in PMC

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