Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Aug;15(8):634-9.
doi: 10.5152/akd.2014.5645. Epub 2014 Jun 23.

Relationship between red cell distribution width and long-term mortality in patients with non-ST elevation acute coronary syndrome

Adem Bekler  1 , Erhan Tenekecioğlu, Gökhan Erbağ, Ahmet Temiz, Burak Altun, Ahmet Barutçu, Emine Gazi, Fahri Güneş, Mustafa Yılmaz
Affiliations

Relationship between red cell distribution width and long-term mortality in patients with non-ST elevation acute coronary syndrome

Adem Bekler et al. Anatol J Cardiol. 2015 Aug.

Abstract

Objective: Red cell distribution width (RDW) has been reported to be a predictor of cardiac events in coronary artery disease (CAD). Here, we hypothesized that RDW level on admission would be predictive of adverse outcomes in non-ST elevation acute coronary syndrome (NST-ACS).

Methods: In total, 202 patients with NST-ACS (159 males and 43 females) were retrospectively analyzed. The patients were divided into two groups based on the 50th percentile of admission RDW levels. A high RDW group (n=100) was defined as those patients having RDW levels of >14.0. The relationship between RDW and primary endpoint (cardiovascular death), secondary endpoints [(reinfarction, repeat target vessel revascularization-percutaneous/surgical)], and major adverse cardiac events (MACE) were assessed. The median follow-up time was 18 (13-24) months.

Results: The patients in the high RDW group were older (62.9 vs. 57.5, p = 0.001). Multivessel disease, low-density lipoprotein, creatinine, platelet, CK-MB, troponin I, and RDW were higher (p = 0.047, p = 0.003, p = 0.012, p = 0.012, p = 0.017, p < 0.001, respectively), and gender (male/female), ejection fraction, and hemoglobin levels were lower (p = 0.021, p = 0.04, p = 0.016, respectively) in the high RDW group. Cardiovascular death and MACE were higher in the high RDW group (16% vs. 4.9%, p = 0.01, 52% vs. 31.4%, p = 0.003, respectively). By multiple regression analysis in 202 patients, age ≥ 65 and RDW >14.0% on admission were found to be powerful independent predictors of cardiovascular mortality (OR: 4.5, 95% CI: 1.5-13.1, p = 0.005, OR: 3.0, 95% CI: 1.0-8.9, p = 0.039, respectively).

Conclusion: A high RDW level on admission is associated with increased long-term mortality in patients with NST-ACS.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Receiver operating characteristic (ROC) curve analysis to determine the best cut-off value for the relationship between red cell distribution width and cardiovascular death
See this image and copyright information in PMC

Comment in

References

    1. Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation. 2008;117:163–8. [CrossRef] - PubMed
    1. Van Kimmenade RR, Mohammed AA, Uthamalingam S, Van der Meer P, Felker GM, Januzzi JL., Jr Red blood cell distribution width and 1-year mortality in acute heart failure. Eur J Heart Fail. 2010;12:129–36. [CrossRef] - PubMed
    1. Ani C, Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke. J Neurol Sci. 2009;277:103–8. [CrossRef] - PubMed
    1. Uyarel H, Ergelen M, Çicek G, Kaya MG, Ayhan E, Türkkan C, et al. Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction. Coron Artery Dis. 2011;22:138–44. [CrossRef] - PubMed
    1. Weiss G, Goodnough LT. Anemia of chronic disease. New Engl J Med. 2005;352:1011–23. [CrossRef] - PubMed

Publication types

LinkOut - more resources