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. 2014 Dec;35 Suppl 1(Suppl 1):S29-35.

Epidemiology of neural tube defects

Mohammed Z Seidahmed  1 , Omar B Abdelbasit, Meeralebbae M Shaheed, Khalid A Alhussein, Abeer M Miqdad, Mohamed I Khalil, Naif M Al-Enazy, Mustafa A Salih
Affiliations

Epidemiology of neural tube defects

Mohammed Z Seidahmed et al. Saudi Med J. 2014 Dec.

Abstract

Objective: To find the prevalence of neural tube defects (NTDs), and compare the findings with local and international data, and highlight the important role of folic acid supplementation and flour fortification with folic acid in preventing NTDs.

Methods: This is a retrospective study of data retrieved from the medical records of live newborn infants admitted to the Neonatal Intensive Care Unit (NICU), Security Forces Hospital (SFH), Riyadh, Saudi Arabia with NTDs spanning 14 years (1996-2009). All pregnant women on their first antenatal visit to the primary care clinic were prescribed folic acid 0.5 mg daily, or 5 mg if there is a family history of NTD. The pre-fortification prevalence is compared to post-fortification, before and after excluding syndromic, genetic, and chromosomal causes. The results were compared with reports from other parts of Saudi Arabia and internationally, through a literature search using MEDLINE.

Results: The prevalence of NTDs during the period was 1.2 per 1000 live births. The pre-fortification of flour with folic acid prevalence was 1.46 per 1000 live births. The post-fortification prevalence was 1.05 (p=0.103). After excluding syndromic, genetic, and chromosomal causes from calculation of the prevalence, there was a significant reduction in the prevalence, from 1.46 to 0.81 per 1000 live births (p=0.0088). Syndromic, genetic, and chromosomal causes were identified in 20 cases (19.4%). Only 2% of mothers received preconception folic acid, and only 10% of them received it during the first 4 weeks of gestation.

Conclusion: Despite the implementation of fortification of flour with folic acid since 2001, the prevalence of NTDs in the Kingdom of Saudi Arabia is still high. This is due to the impact of genetic, syndromic, and chromosomal causes of NTD not preventable by folic acid. Other factors like unplanned pregnancy and lack of awareness of the role of folic acid in preventing nonsyndromic causes, play a significant role.

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Figures

Figure 1
Figure 1
Comparison between pre-fortification (1996-2000) and post-fortification (2001-2009) prevalence of neural tube defectswith, and without syndromic causes.
See this image and copyright information in PMC

Comment in

  • Epidemiology of neural tube defects.
    Al-Mendalawi MD. Al-Mendalawi MD. Saudi Med J. 2015 Mar;36(3):373-4. doi: 10.15537/smj.2015.3.11087. Saudi Med J. 2015. PMID: 25737186 Free PMC article. No abstract available.
  • Reply from the author.
    Seidahmed MZ. Seidahmed MZ. Saudi Med J. 2015 Mar;36(3):373-4. Saudi Med J. 2015. PMID: 25906481 No abstract available.

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