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Editorial
. 2015 Feb 10;131(6):522-4.
doi: 10.1161/CIRCULATIONAHA.114.014420. Epub 2014 Dec 31.

What the dead can teach the living: systemic nature of heart failure with preserved ejection fraction

Affiliations
Editorial

What the dead can teach the living: systemic nature of heart failure with preserved ejection fraction

Dalane W Kitzman et al. Circulation. .
No abstract available

Keywords: Editorials; aging; autopsy; comorbidity; coronary artery disease; fibrosis; heart failure; hypertrophy; inflammation; left ventricular.

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Conflict of interest statement

Disclosures: Dr. Kitzman declares the following relationships: Consultant for Abbvie, Relypsa, Regeneron, DC Devices, and Actavis, grant funding from Novartis, and stock ownership in Gilead Sciences and Relypsa. No other members of the writing group have conflicts of interest to declare.

Figures

Figure 1
Figure 1
Capillary density (capillary-to-fiber ratio) from thigh muscle biopsy in elderly patients with HFPEF and age-matched control subjects. Adapted from Kitzman et al; Am J Physiol Heart Circ Physiol 2014;306:H1364–1370.
Figure 2
Figure 2
Relationship of capillary density (capillary-to-fiber ratio) with peak exercise O2 uptake (V˙o2), an objective measure of exercise capacity, in older patients with HFPEF (■) and age-matched control subjects (▲). From Kitzman et al with permission.

Comment on

References

    1. Gottdiener JS, Arnold AM, Aurigemma GP, Polak JF, Tracy RP, Kitzman DW, Gardin JM, Rutledge JE, Boineau RC. Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study. J Am Coll Cardiol. 2000;35:1628–1637. - PubMed
    1. Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med. 2006;355:251–259. - PubMed
    1. Mohammed SF, Hussain S, Mirzoyev SA, Edwards WD, Maleszewski JJ, Redfield MM. Coronary microvascular rarefaction and myocardial fibrosis in heart failure with preserved ejection fraction. Circulation. 2015;131:XX–XXX. - PMC - PubMed
    1. Putko BN, Wang Z, Lo J, Anderson T, Becher H, Dyck JR, Kassiri Z, Oudit GY, on behalf of the Alberta HEART Investigators Circulating levels of tumor necrosis factor-alpha receptor 2 are increased in heart failure with preserved ejection fraction relative to heart failure with reduced ejection fraction: evidence for a divergence in pathophysiology. PLoS ONE. 2014;9:e99495. - PMC - PubMed
    1. Rando T, Finkel T. Cardiac Aging and Rejuvenation–A Sense of Humors? N Engl J Med. 2013;369:575–576. - PubMed