Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2014 Dec 31;4(12):e007065.
doi: 10.1136/bmjopen-2014-007065.

A randomised controlled trial of aerobic exercise after transient ischaemic attack or minor stroke to prevent cognitive decline: the MoveIT study protocol

H M Boss  1 , S M Van Schaik  1 , I A Deijle  2 , E C de Melker  3 , B T J van den Berg  4 , E J A Scherder  5 , W M J Bosboom  1 , H C Weinstein  1 , R M Van den Berg-Vos  1
Affiliations
Randomized Controlled Trial

A randomised controlled trial of aerobic exercise after transient ischaemic attack or minor stroke to prevent cognitive decline: the MoveIT study protocol

H M Boss et al. BMJ Open. .

Abstract

Introduction: Patients with transient ischaemic attack (TIA) or stroke are at risk for cognitive impairment and dementia. Currently, there is no known effective strategy to prevent this cognitive decline. Increasing evidence exists that physical exercise is beneficial for cognitive function. However, in patients with TIA or stroke who are at risk of cognitive impairment and dementia, only a few trials have been conducted. In this study, we aim to investigate whether a physical exercise programme (MoveIT) can prevent cognitive decline in patients in the acute phase after a TIA or minor ischaemic stroke.

Methods and analysis: A single-blinded randomised controlled trial will be conducted to investigate the effect of an aerobic exercise programme on cognition compared with usual care. 120 adult patients with a TIA or minor ischaemic stroke less than 1 month ago will be randomly allocated to an exercise programme consisting of a 12-week aerobic exercise programme and regular follow-up visits to a specialised physiotherapist during the period of 1 year or to usual care. Outcome measures will be assessed at the baseline, and at the 1-year and 2-year follow-up. The primary outcome is cognitive functioning measured with the Montreal Cognitive Assessment (MoCA) test and with additional neuropsychological tests. Secondary outcomes include maximal exercise capacity, self-reported physical activity and measures of secondary prevention.

Ethics and dissemination: The study received ethical approval from the VU University Amsterdam Ethics committee (2011/383). The results of this study will be published in peer-reviewed journals and presented at international conferences. We will also disseminate the main results to our participants in a letter.

Trial registration number: The Nederlands Trial Register NTR3884.

Keywords: SPORTS MEDICINE.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow chart of trial design.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Pendlebury ST, Rothwell PM. Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis. Lancet Neurol 2009;8:1006–18. 10.1016/S1474-4422(09)70236-4 - DOI - PubMed
    1. Gottesman RF, Hillis AE. Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke. Lancet Neurol 2010;9:895–905. 10.1016/S1474-4422(10)70164-2 - DOI - PMC - PubMed
    1. Moran GM, Fletcher B, Feltham MG et al. . Fatigue, psychological and cognitive impairment following transient ischaemic attack and minor stroke: a systematic review. Eur J Neurol 2014;21:1258–67. 10.1111/ene.12469 - DOI - PubMed
    1. van Rooij FG, Schaapsmeerders P, Maaijwee NAM et al. . Persistent cognitive impairment after transient ischemic attack. Stroke 2014;45:2270–4. 10.1161/STROKEAHA.114.005205 - DOI - PubMed
    1. Dong Y, Slavin MJ, Chan BP-L et al. . Improving screening for vascular cognitive impairment at three to six months after mild ischemic stroke and transient ischemic attack. Int Psychogeriatr 2014;26:787–93. 10.1017/S1041610213002457 - DOI - PubMed

Publication types

Associated data

LinkOut - more resources