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Review
. 2015 Jan 1;11(1):31-7.
doi: 10.7150/ijbs.10615. eCollection 2015.

Epithelial cell polarity determinant CRB3 in cancer development

Pingping Li  1 , Xiaona Mao  1 , Yu Ren  2 , Peijun Liu  1
Affiliations
Review

Epithelial cell polarity determinant CRB3 in cancer development

Pingping Li et al. Int J Biol Sci. .

Abstract

Cell polarity, which is defined as asymmetry in cell shape, organelle distribution and cell function, is essential in numerous biological processes, including cell growth, cell migration and invasion, molecular transport, and cell fate. Epithelial cell polarity is mainly regulated by three conserved polarity protein complexes, the Crumbs (CRB) complex, partitioning defective (PAR) complex and Scribble (SCRIB) complex. Research evidence has indicated that dysregulation of cell polarity proteins may play an important role in cancer development. Crumbs homolog 3 (CRB3), a member of the CRB complex, may act as a cancer suppressor in mouse kidney epithelium and mouse mammary epithelium. In this review, we focus on the current data available on the roles of CRB3 in cancer development.

Keywords: CRB3; EMT; apical-basal polarity; cancer.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Fig 1
Fig 1
Schematic model of cell polarity complexes and cell junction complexes.
Fig 2
Fig 2
Protein domain structures of Drosophila crb and human CRB.
Fig 3
Fig 3
Schematic model of CRB3 in carcinogenesis and Hippo signaling cascade in mammals.
See this image and copyright information in PMC

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