The role and utility of faecal markers in inflammatory bowel disease
- PMID: 25553077
- PMCID: PMC4265086
- DOI: 10.1177/1756283X14553384
The role and utility of faecal markers in inflammatory bowel disease
Abstract
Crohn's disease and ulcerative colitis are characterized by periods of symptomatic relapse and remission. Diagnosis and assessment of inflammatory bowel disease has so far been based on clinical evaluation, serum parameters, radiology and endoscopy. Faecal markers such as calprotectin or lactoferrin have emerged as new diagnostic tools to detect and monitor intestinal inflammation. This review focuses on their potential clinical applications and limitations in the management of inflammatory bowel disease.
Keywords: Crohn’s disease; calprotectin; inflammation; inflammatory bowel disease; lactoferrin; ulcerative colitis.
Conflict of interest statement
References
-
- Annaházi A., Molnár T., Farkas K., Rosztóczy A., Izbéki F., Gecse K., et al. (2013) Fecal MMP-9: a new noninvasive differential diagnostic and activity marker in ulcerative colitis. Inflamm Bowel Dis 19: 316–320. - PubMed
-
- Baugh M., Perry M., Hollander A., Davies D., Cross S., Lobo A., et al. (1999) Matrix metalloproteinase levels are elevated in inflammatory bowel disease. Gastroenterology 117: 814–822. - PubMed
-
- Bernell O., Lapidus A., Hellers G. (2000) Risk factors for surgery and recurrence in 907 patients with primary ileocaecal Crohn’s disease. Br J Surg 87: 1697–1701. - PubMed
-
- Bremner A., Roked S., Robinson R., Phillips I., Beattie M. (2005) Faecal calprotectin in children with chronic gastrointestinal symptoms. Acta Paediatr 94: 1855–1858. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources
