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. 1989 Aug;80(8):716-9.
doi: 10.1111/j.1349-7006.1989.tb01703.x.

Inhibition of in vitro tumor cell invasion by transmethylation inhibitors

K Shinkai  1 , M Mukai, T Horai, H Ohigashi, S Nishikawa, H Inoue, Y Takeda, H Akedo
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Inhibition of in vitro tumor cell invasion by transmethylation inhibitors

K Shinkai et al. Jpn J Cancer Res. 1989 Aug.

Abstract

Three inhibitors of S-adenosylmethionine-mediated transmethylation, 5'-methylthioadenosine (MTA), 2'-deoxyadenosine and sinefungin, inhibited in vitro invasion by a highly invasive clone (Cl-30) of rat ascites hepatoma cells, AH 130 (AH cells). Difluoromethylthioadenosine (DFMTA), a non-metabolizable derivative of MTA, also caused strong inhibition of invasion at concentrations that did not suppress the growth of the tumor cells. Cl-30 cells precultured in methionine-depleted medium showed decreased invasiveness. DFMTA was also effective on the invasion by fibrosarcoma, B16 melanoma and human lung carcinoma cell lines.

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References

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