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. 2015 Jan;7(1):38-44.
doi: 10.1177/1941738114529727.

Current concepts: the role of mesenchymal stem cells in the management of knee osteoarthritis

Jesse I Wolfstadt  1 , Brian J Cole  2 , Darrell J Ogilvie-Harris  3 , Sowmya Viswanathan  4 , Jaskarndip Chahal  3
Affiliations

Current concepts: the role of mesenchymal stem cells in the management of knee osteoarthritis

Jesse I Wolfstadt et al. Sports Health. 2015 Jan.

Abstract

Context: The number of adults with osteoarthritis in the United States is expected to nearly double from 21.4 million in 2005 to 41.1 million by 2030. As a result, medical costs and associated comorbidity will exponentially increase in the coming decades. In the past decade, mesenchymal stem cells (MSCs) have emerged as a novel treatment for degenerative joint disease.

Evidence acquisition: PubMed (from 1990 to 2013) was searched to identify relevant studies. Reference lists of included studies were also reviewed.

Study design: Clinical review.

Level of evidence: Level 3.

Results: We identified 9 animal and 7 human studies investigating the use of MSCs in the treatment of osteoarthritis, with varying levels of support for this therapy.

Conclusion: While MSCs have shown potential for improving function and decreasing inflammation in animal studies, translation to patients is still in question. There is a great deal of heterogeneity in treatment methods. Standardizing the manufacturing and characterization of MSCs will allow for better comparisons.

Keywords: mesenchymal stem cells; osteoarthritis; treatment.

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Conflict of interest statement

The following authors declared potential conflicts of interest: Sowmya Viswanathan, PhD, is a paid consultant for Centre for Commercialization of Regenerative Medicine and CEO of Cellulead. Brian J. Cole, MD, MBA, is a paid consultant for DePuy, Arthrex, Regentis, Zimmer, and Carticept; has grants/grant pending from S&N; receives royalties from Arthrex, DePuy, Elsevier, WB Saunders; and hold stock/stock options in Carticept and Regentis.

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References

    1. Al Faqeh H, Nor Hamdan BM, Chen HC, Aminuddin BS, Ruszymah BH. The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. Exp Gerontol. 2012;47:458-464. - PubMed
    1. Barry F, Murphy M. Mesenchymal stem cells in joint disease and repair. Nat Rev Rheumatol. 2013;9:584-594. - PubMed
    1. Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G. Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev. 2006;(2):CD005321. - PMC - PubMed
    1. Ben-David U, Benvenisty N. The tumorigenicity of human embryonic and induced pluripotent stem cells. Nat Rev Cancer. 2011;11:268-277. - PubMed
    1. Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377:2115-2126. - PubMed