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. 2015 Jan;5(1):32-4.
doi: 10.1177/1941874414528939.

Hallucinogens causing seizures? A case report of the synthetic amphetamine 2,5-dimethoxy-4-chloroamphetamine

Mark J Burish  1 , Katie L Thoren  2 , Maura Madou  1 , Shahed Toossi  1 , Maulik Shah  1
Affiliations

Hallucinogens causing seizures? A case report of the synthetic amphetamine 2,5-dimethoxy-4-chloroamphetamine

Mark J Burish et al. Neurohospitalist. 2015 Jan.

Abstract

Although traditional hallucinogenic drugs such as marijuana and lysergic acid diethylamide (LSD) are not typically associated with seizures, newer synthetic hallucinogenic drugs can provoke seizures. Here, we report the unexpected consequences of taking a street-bought hallucinogenic drug thought to be LSD. Our patient presented with hallucinations and agitation progressing to status epilepticus with a urine toxicology screen positive only for cannabinoids and opioids. Using liquid chromatography high-resolution mass spectrometry, an additional drug was found: an amphetamine-derived phenylethylamine called 2,5-dimethoxy-4-chloroamphetamine. We bring this to the attention of the neurologic community as there are a growing number of hallucinogenic street drugs that are negative on standard urine toxicology and cause effects that are unexpected for both the patient and the neurologist, including seizures.

Keywords: epilepsy; neurochemistry; neuropharmacology; neurotoxicity syndromes; seizures; techniques.

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Conflict of interest statement

Declaration of Conflicting Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Leach JP, Mohanraj R, Borland W. Alcohol and drugs in epilepsy: pathophysiology, presentation, possibilities, and prevention. Epilepsia. 2012;53(suppl 4):48–57. - PubMed
    1. Ng SK, Brust JC, Hauser WA, Susser M. Illicit drug use and the risk of new-onset seizures. Am J Epidemiol. 1990;132(1):47–57. - PubMed
    1. Havenon AD, Chin B, Thomas KC, Afra P. The secret “spice”: an undetectable toxic cause of seizure. Neurohospitalist. 2011;1(4):182–186. - PMC - PubMed
    1. Armenian P, Mamantov TM, Tsutaoka BT, et al. Multiple MDMA (Ecstasy) overdoses at a rave event: a case series. J Intensive Care Med. 2013;28(4):252–258. - PubMed
    1. Gerona RR, Wu AHB. Bath salts. Clin Lab Med. 2012;32(3):415–427. - PubMed

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