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Case Reports
. 2015 Jan;35(1):178-80.
doi: 10.3343/alm.2015.35.1.178. Epub 2014 Dec 8.

Identification of somatic KRAS mutation in a Korean baby with nevus sebaceus syndrome

Sung Woo Kim  1 , Ju Sun Song  2 , Mi Seon Kang  3 , Jong Beom Sin  1 , Chang-Seok Ki  2 , Ga Won Jeon  1
Affiliations
Case Reports

Identification of somatic KRAS mutation in a Korean baby with nevus sebaceus syndrome

Sung Woo Kim et al. Ann Lab Med. 2015 Jan.
No abstract available

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Conflict of interest statement

No potential conflicts of interest to this article were reported.

Figures

Fig. 1
Fig. 1
Clinical features of nevus sebaceus. (A) Well-demarcated slippery, skin-colored, orange-peel like, linear plaque on the patient's left parietal scalp and face. (B) Round plaque on the patient's occipital scalp, showing alopecia. (C) A limbal dermoid with a skin-colored pedunculated papule on the left eyelid.
Fig. 2
Fig. 2
Pathology of nevus sebaceus showing proliferative changes of sebaceous glands and apocrine glands in the epidermis (H&E, ×100).
Fig. 3
Fig. 3
The KRAS mutation (c.35G>A; p.Gly12Asp) was identified in genomic DNA isolated from the nevus sebaceus lesion (arrows), but not from adjacent normal skin tissue or peripheral blood leukocytes.
See this image and copyright information in PMC

References

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