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Review
. 2015 Jan 1;20(3):440-57.
doi: 10.2741/4318.

Poly-ADP-ribosylation signaling during DNA damage repair

Barbara Golia  1 , Hari R Singh  1 , Gyula Timinszky  1
Affiliations
Review

Poly-ADP-ribosylation signaling during DNA damage repair

Barbara Golia et al. Front Biosci (Landmark Ed). .

Abstract

Poly-ADP-ribosylation is a post-translational modification generated in high amounts by poly-ADP-ribose polymerases (PARPs) in response to cellular stress, especially genotoxic stimuli. DNA damage-induced PARylation significantly changes local chromatin structure and triggers the accumulation of several DNA damage response (DDR) proteins at the DNA lesions. In this review, we will discuss the regulation of chromatin structure and DNA damage repair machineries by DNA damage-induced poly-ADP-ribosylation.

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