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. 2015 Mar 15:139:43-8.
doi: 10.1016/j.saa.2014.12.033. Epub 2014 Dec 20.

Hydrolysis of Letrozole catalyzed by macrocyclic Rhodium (I) Schiff-base complexes

P Muralidhar Reddy  1 , K Shanker  2 , V Srinivas  2 , E Ravi Krishna  2 , R Rohini  3 , G Srikanth  2 , Anren Hu  4 , V Ravinder  5
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Hydrolysis of Letrozole catalyzed by macrocyclic Rhodium (I) Schiff-base complexes

P Muralidhar Reddy et al. Spectrochim Acta A Mol Biomol Spectrosc. .

Abstract

Ten mononuclear Rhodium (I) complexes were synthesized by macrocyclic ligands having N4 and N2O2 donor sites. Square planar geometry is assigned based on the analytical and spectral properties for all complexes. Rh(I) complexes were investigated as catalysts in hydrolysis of Nitrile group containing pharmaceutical drug Letrozole. A comparative study showed that all the complexes are efficient in the catalysis. The percent yields of all the catalytic reaction products viz. drug impurities were determined by spectrophotometric procedures and characterized by spectral studies.

Keywords: Hydrolysis; Letrozole; Rhodium (I) complexes; Spectral studies; Spectrophotometry.

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