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. 1989 Dec;63(12):5492-6.
doi: 10.1128/JVI.63.12.5492-5496.1989.

Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus

R P Roos  1 , S Stein, Y Ohara, J L Fu, B L Semler
Affiliations

Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus

R P Roos et al. J Virol. 1989 Dec.

Abstract

The DA strain and other members of the TO subgroup of Theiler's murine encephalomyelitis viruses cause a persistent demyelinating infection, whereas the GDVII strain and other GDVII subgroup strains cause an acute lethal polioencephalomyelitis. We generated an infectious DA cDNA clone inserted into a transcription vector. Virus derived from transfection of transcripts produced a demyelinating disease indistinguishable from that of wild-type virus. The infectious clone provides a critical reagent for the production of interstrain recombinant viruses to help identify genetic loci responsible for the biological activities of the strains.

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