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Comment
. 2015 Feb 27;427(4):707-714.
doi: 10.1016/j.jmb.2014.12.017. Epub 2014 Dec 31.

Titin and obscurin: giants holding hands and discovery of a new Ig domain subset

Guy M Benian  1 , Olga Mayans  2
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Titin and obscurin: giants holding hands and discovery of a new Ig domain subset

Guy M Benian et al. J Mol Biol. .
No abstract available

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Figures

Fig. 1
Fig. 1
Crystal structures of titin M10 in complex with Obs O1 and Obsl1 OL1. Complexes (PDB codes 4C4K and 2WP3) are displayed superimposed on the Obs/Obsl1 partners. For visual clarity, only one copy of M10 is displayed. The structural conservation of the Obs/Obsl1 domains is very high, with a significant divergence only present in β-strand A′ and the subsequent AB loop. The β-hairpin FG mediating the interaction in Obs/Obsl1 is one of the most conserved regions in these domains (strictly conserved residues are in boldface; the NxxG signature motif of this hairpin as described in Marino et al. [64] is in red). The AB loop, despite its different conformation, retains a close sequence resemblance.
Fig. 2
Fig. 2
Crystal structures of filamentous assemblies. Deviant N-terminal features in Ig domains are highlighted in cyan. In Obs and myomesin, cyan indicates the β-hairpin AB (and the loop it forms) as characteristic of the new I*-Ig set. In D. discoideum filamin (DdFilamin), the dimerizing Ig has an incomplete set of strands so that the colored β-strand in N-terminal position is B. PDB accession codes are as follows: (a) 4C4K, (b) 1V05, (c) 1YA5, (d) 2Y25 and (e) 1WLH.
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References

    1. Benian GM, Kiff JE, Neckelmann N, Moerman DG, Waterston RH. Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans. Nature. 1989;342:45–50. - PubMed
    1. Benian GM, L’Hernault SW, Morris ME. Additional sequence complexity in the muscle gene, unc-22, and its encoded protein, twitchin, of Caenorhabditis elegans. Genetics. 1993;134:1097–104. - PMC - PubMed
    1. Labeit S, Barlow DP, Gautel M, Gibson T, Holt J, Hsieh CL, et al. A regular pattern of two types of 100-residue motif in the sequence of titin. Nature. 1990;345:273–6. - PubMed
    1. Labeit S, Kolmerer B. Titins: giant proteins in charge of muscle ultrastructure and elasticity. Science. 1995;270:293–6. - PubMed
    1. Kontrogianni-Konstantopoulos A, Ackermann MA, Bowman AL, Yap SV, Bloch RJ. Muscle giants: molecular scaffolds in sarcomerogenesis. Physiol Rev. 2009;89:1217–67. - PMC - PubMed

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