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Review
. 2015 May;9(5):1008-17.
doi: 10.1016/j.molonc.2014.12.006. Epub 2014 Dec 20.

Cancer chemoprevention: Much has been done, but there is still much to do. State of the art and possible new approaches

Davide Serrano  1 , Matteo Lazzeroni  1 , Bernardo Bonanni  2
Affiliations
Review

Cancer chemoprevention: Much has been done, but there is still much to do. State of the art and possible new approaches

Davide Serrano et al. Mol Oncol. 2015 May.

Abstract

Over the past three decades great efforts have been made in search of cancer chemoprevention strategies. The increase in knowledge of the long process from normal to cancer cell has enabled interventions in terms of lifestyle modifications, natural compounds or drugs to block or reverse the process. Great successes have been achieved, especially for breast and colorectal cancer. However, these strategies have yet to find clinical application on a large scale. In this article we identify the achievements, the pitfalls and the next steps to be taken to improve the efficacy and applicability of chemoprevention strategies. Among the crucial key points to be implemented are educational activities for physicians to appropriately disseminate the aim and indeed the culture of chemoprevention. It is essential to improve the risk-benefit balance, seeking the minimal active doses, intermittent schedules, a better characterization of the risk categories via a more personalized intervention based on individual characteristics, and ensure the containment of costs of public and private health prevention programs.

Keywords: Chemoprevention; Surrogate-biomarkers; Vaccines.

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References

    1. Ahn, J. , Sinha, R. , Pei, Z. , Dominianni, C. , Wu, J. , Shi, J. , Goedert, J.J. , Hayes, R.B. , Yang, L. , 2013. Human gut microbiome and risk for colorectal cancer. J. Natl. Cancer Inst. 105, 1907–1911. - PMC - PubMed
    1. Albanes, D. , Heinonen, O.P. , Taylor, P.R. , Virtamo, J. , Edwards, B.K. , Rautalahti, M. , Hartman, A.M. , Palmgren, J. , Freedman, L.S. , Haapakoski, J. , Barrett, M.J. , Pietinen, P. , Malila, N. , Tala, E. , Liippo, K. , Salomaa, E.R. , Tangrea, J.A. , Teppo, L. , Askin, F.B. , Taskinen, E. , Erozan, Y. , Greenwald, P. , Huttunen, J.K. , 1996. Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. J. Natl. Cancer Inst. 88, 1560–1570. - PubMed
    1. Alberts, D.S. , Martinez, M.E. , Roe, D.J. , Guillen-Rodriguez, J.M. , Marshall, J.R. , van Leeuwen, J.B. , Reid, M.E. , Ritenbaugh, C. , Vargas, P.A. , Bhattacharyya, A.B. , Earnest, D.L. , Sampliner, R.E. , 2000. Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians' Network. N. Engl. J. Med. 342, 1156–1162. - PubMed
    1. Arber, N. , Eagle, C.J. , Spicak, J. , Racz, I. , Dite, P. , Hajer, J. , Zavoral, M. , Lechuga, M.J. , Gerletti, P. , Tang, J. , Rosenstein, R.B. , Macdonald, K. , Bhadra, P. , Fowler, R. , Wittes, J. , Zauber, A.G. , Solomon, S.D. , Levin, B. , 2006. Celecoxib for the prevention of colorectal adenomatous polyps. N. Engl. J. Med. 355, 885–895. - PubMed
    1. Baker, S.G. , Kramer, B.S. , 2013. Surrogate endpoint analysis: an exercise in extrapolation. J. Natl. Cancer Inst. 105, 316–320. - PMC - PubMed

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