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Comparative Study
. 1989 Dec;9(12):5718-21.
doi: 10.1128/mcb.9.12.5718-5721.1989.

Definition of an Ets1 protein domain required for nuclear localization in cells and DNA-binding activity in vitro

K E Boulukos  1 , P Pognonec, B Rabault, A Begue, J Ghysdael
Affiliations
Comparative Study

Definition of an Ets1 protein domain required for nuclear localization in cells and DNA-binding activity in vitro

K E Boulukos et al. Mol Cell Biol. 1989 Dec.

Abstract

Ets1 and Ets2 are nuclear phosphoproteins which bind to DNA in vitro and share two domains of strong identity. Deletion analyses of each of these conserved regions in Ets1 demonstrated that integrity of the carboxy-terminal domain, also conserved in the more distantly related elk and erg gene products, is essential for both nuclear targeting and DNA-binding activity in vitro.

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References

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