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Review
. 2015 Apr;17(4):451-66.
doi: 10.1111/cmi.12413. Epub 2015 Feb 4.

The cell biology of malaria infection of mosquito: advances and opportunities

R E Sinden  1
Affiliations
Review

The cell biology of malaria infection of mosquito: advances and opportunities

R E Sinden. Cell Microbiol. 2015 Apr.

Abstract

Recent reviews (Feachem et al.; Alonso et al.) have concluded that in order to have a sustainable impact on the global burden of malaria, it is essential that we knowingly reduce the global incidence of infected persons. To achieve this we must reduce the basic reproductive rate of the parasites to < 1 in diverse epidemiological settings. This can be achieved by impacting combinations of the following parameters: the number of mosquitoes relative to the number of persons, the mosquito/human biting rate, the proportion of mosquitoes carrying infectious sporozoites, the daily survival rate of the infectious mosquito and the ability of malaria-infected persons to infect mosquito vectors. This paper focuses on our understanding of parasite biology underpinning the last of these terms: infection of the mosquito. The article attempts to highlight central issues that require further study to assist in the discovery of useful transmission-blocking measures.

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Figures

Figure 1
Figure 1
Some of the earlier and significant steps in the analysis of the cell biology of sexual development of Plasmodium spp. [Table: see text]
See this image and copyright information in PMC

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