Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Nov 30;342(6249):505-11.
doi: 10.1038/342505a0.

Specific proteolysis of the c-mos proto-oncogene product by calpain on fertilization of Xenopus eggs

N Watanabe  1 , G F Vande Woude, Y Ikawa, N Sagata
Affiliations

Specific proteolysis of the c-mos proto-oncogene product by calpain on fertilization of Xenopus eggs

N Watanabe et al. Nature. .

Abstract

The Xenopus c-mos proto-oncogene product, pp39mos, accumulates in the unfertilized egg during maturation, is hyperphosphorylated and exhibits protein kinase activity. On fertilization, or soon after the completion of meiosis, the accumulated pp39mos undergoes selective proteolysis. Using an in vitro protease assay system, we show here that this specific proteolysis is caused by the calcium-dependent cysteine protease, calpain.

PubMed Disclaimer

Comment in

Publication types

LinkOut - more resources