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. 2014 Nov 1;9(21):1880-1.
doi: 10.4103/1673-5374.145349.

Neuroactive alkaloids that modulate the neuronal nicotinic receptor and provide neuroprotection in an Alzheimer's disease model: the case of Teline monspessulana

Jorge Fuentealba  1 , Francisco Saez-Orellana  1
Affiliations

Neuroactive alkaloids that modulate the neuronal nicotinic receptor and provide neuroprotection in an Alzheimer's disease model: the case of Teline monspessulana

Jorge Fuentealba et al. Neural Regen Res. .
No abstract available

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Figures

Figure 1
Figure 1
(A) Galanthus nivalis, the plant from where galantamine was first isolated, showing its characteristic flower. (B) Chemical structure of Galantamine. (C) Teline monspessulana the source of TM extract. Note its characteristic yellow flowers and fruit which accumulate quinozilinidinic alkaloids. (D) The chemical structures of quinozilidine and (-)-cytisine, one of the most common quinozilinidinic derivatives.
Figure 2
Figure 2
Schematic representation of the action of alkaloids with potential cholinergic effects in Alzheimer's disease. These alkaloids can modulate acetyl- and/or butyrylcholinesterase (AChE/BuChE) and can also allosterically modulate nAChR, like α7 (central structure in the figure), and promote the activation of the AKT pathway and neuroprotection.
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