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. 2014 Jun;1(2):e961825.
doi: 10.4161/23723548.2014.961825.

Cell survival is dicey without Dicer

Clare M Adams  1 , Christine M Eischen  1
Affiliations

Cell survival is dicey without Dicer

Clare M Adams et al. Mol Cell Oncol. 2014 Jun.

Abstract

The cellular requirements of Dicer, an essential miRNA processing enzyme, and the consequences of altered levels of it on tumorigenesis are incompletely understood. We review the effects of Dicer loss in cells of different origin and whether loss of p53 permits cell survival and growth in the absence of Dicer.

Keywords: Dicer; lymphoma; p53; tumorigenesis.

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Figures

Figure 1.
Figure 1.
p53 inactivation protects some cells from the negative consequences of deletion of Dicer. The p53 tumor suppressor responds to impaired miRNA processing by inducing senescence, cell cycle arrest, or apoptosis. Non-hematopoietic cells that harbor inactivated p53 can survive and grow (albeit possibly more slowly) in the absence of Dicer. In contrast, hematopoietic cells are extremely sensitive to Dicer loss and rapidly undergo apoptosis, regardless of p53 status. *Co-inactivation of the Rb pathway with p53 results in synthetic lethality.
See this image and copyright information in PMC

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