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Review
. 2015 Feb;12(2):69-70.
doi: 10.1038/nrclinonc.2014.223. Epub 2015 Jan 6.

Glioma in 2014: unravelling tumour heterogeneity-implications for therapy

David A Reardon  1 , Patrick Y Wen  1
Affiliations
Review

Glioma in 2014: unravelling tumour heterogeneity-implications for therapy

David A Reardon et al. Nat Rev Clin Oncol. 2015 Feb.

Abstract

Heterogeneity within and across tumours is increasingly recognized as a critical factor that limits therapeutic progress for many cancers. Key studies reported in 2014 describe previously unappreciated patterns of geographical and temporal heterogeneity for glioblastoma (the most-common primary CNS tumour in adults), with important implications for ongoing therapeutic studies evaluating molecular targeted therapies.

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References

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