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. 2015 Feb;11(2):74-6.
doi: 10.1038/nrrheum.2014.219. Epub 2015 Jan 6.

Osteoimmunology in 2014: Two-faced immunology-from osteogenesis to bone resorption

Hiroshi Takayanagi  1
Affiliations

Osteoimmunology in 2014: Two-faced immunology-from osteogenesis to bone resorption

Hiroshi Takayanagi. Nat Rev Rheumatol. 2015 Feb.

Abstract

Even though activation of immunity is associated with bone destruction, new mechanisms have been described in 2014 through which immunology-associated pathways can cooperate to support osteogenesis. These advances support the view of the immune system as a central mechanism which can regulate bone homeostasis, regeneration and destruction.

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