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Comment
. 2015 Jan;123(1):A23.
doi: 10.1289/ehp.123-A23.

Potential mitochondrial toxicants: Tox21 screen identifies structures of interest

Carol Potera
Comment

Potential mitochondrial toxicants: Tox21 screen identifies structures of interest

Carol Potera. Environ Health Perspect. 2015 Jan.
No abstract available

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Test chemicals from the Tox21 library were arranged in 651 clusters based on structural similarity. Compared with the library overall, “enriched” clusters showed above-average evidence of harming mitochondria, reflected as a decrease in MMP. Identifying structural features associated with decreased MMP allows researchers to choose appropriate candidate chemicals for further research. Source: Attene-Ramos et al. (2015)
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References

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