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Editorial
. 2015 Jan 6;12(1):e1001775.
doi: 10.1371/journal.pmed.1001775. eCollection 2015 Jan.

Randomized controlled trials in environmental health research: unethical or underutilized?

Ryan W Allen  1 , Prabjit K Barn  1 , Bruce P Lanphear  2
Affiliations
Editorial

Randomized controlled trials in environmental health research: unethical or underutilized?

Ryan W Allen et al. PLoS Med. .

Abstract

Ryan Allen and colleagues argue that more randomized controlled trials in environmental health would complement a strong tradition of observational research.

Please see later in the article for the Editors' Summary

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Conflict of interest statement

RWA has received grant and/or contract support from the Canadian Institutes of Health Research, Health Canada, the British Columbia (BC) Ministry of Environment, the BC Lung Association, and the Allergy, Genes, and Environment Network. He has received honoraria for committee participation, peer review, etc. from the BC Lung Association, the Health Effects Institute, and the US EPA. He has received travel funds from the Universidad del Valle (Colombia), the Montreal Department of Public Health, and the Allergy, Genes, and Environment Network. PKB has received research funding, scholarships, and awards from the Air & Waste Management Association, British Columbia Environmental and Occupational Health Research Network, Canadian Institutes of Health Research, Canadian International Development Agency, Fraser Basin Council, Provincial Health Services Authority, Simon Fraser University, and the Vancouver Foundation. BPL has served as an expert witness and as a consultant to the California Attorney General's Office and in a California public nuisance case against the paint and pigment industry, but he has not personally received any compensation for these services. BL has also served as a paid consultant on a US Environmental Protection Agency research study and the California Department of Toxic Substances. He has received NIH, US EPA and Canadian Institutes for Health Research grant support.

References

    1. Grimes DA, Schulz KF (2012) False Alarms and Pseudo-Epidemics The Limitations of Observational Epidemiology. Obstet Gynecol 120: 920–927. - PubMed
    1. Taubes G (1995) Epidemiology Faces Its Limits. Science 269: 164–169. - PubMed
    1. Smith GD, Ebrahim S (2002) Data dredging, bias, or confounding. BMJ 325: 1437–1438. - PMC - PubMed
    1. Burnett RT, Pope CA, Ezzati M, Olives C, Lim SS, et al. (2014) An integrated risk function for estimating the global burden of disease attributable to ambient fine particulate matter exposure. Environ Health Perspect 122: 397–403. - PMC - PubMed
    1. Lanphear BP, Hornung R, Khoury J, Yolton K, Baghurstl P, et al. (2005) Low-level environmental lead exposure and children's intellectual function: An international pooled analysis. Environ Health Perspect 113: 894–899. - PMC - PubMed

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