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Comparative Study
. 2014;15 Suppl 12(Suppl 12):S5.
doi: 10.1186/1471-2164-15-S12-S5. Epub 2014 Dec 19.

Exhaustive data mining comparison of the effects of low doses of ionizing radiation, formaldehyde and dioxins

Alexey Moskalev, Mikhail Shaposhnikov, Ekaterina Plyusnina, Sergey Plyusnin, Olga Shostal, Alexander Aliper, Alex Zhavoronkov
Comparative Study

Exhaustive data mining comparison of the effects of low doses of ionizing radiation, formaldehyde and dioxins

Alexey Moskalev et al. BMC Genomics. 2014.

Abstract

Background: Ionizing radiation in low doses is the ubiquitous environmental factor with harmful stochastic effects. Formaldehyde is one of the most reactive household and industrial pollutants. Dioxins are persistent organic pollutants and most potent synthetic poisons effective even at trace concentrations. Environmental pollutants are capable of altering the expression of a variety of genes. To identify the similarities and differences in the effects of low-dose ionizing radiation, formaldehyde and dioxin on gene expression, we performed the bioinformatic analysis of all available published data.

Results: We found that that in addition to the common p53-, ATM- and MAPK-signaling stress response pathways, genes of cell cycle regulation and proinflammatory cytokines, the studied pollutants induce a variety of other molecular processes.

Conclusions: The observed patterns provide new insights into the mechanisms of the adverse effects associated with these pollutants. They can also be useful in the development of new bio-sensing methods for detection of pollutants in the environment and combating the deleterious effects.

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Figures

Figure 1
Figure 1
Interactions between the activated gene products in ionizing radiation group. For figures 1 to 3: The activation and inhibition interactions between proteins are shown using green and red arrows respectively. Group relationships between proteins are depicted with grey arrows.
Figure 2
Figure 2
Interactions between the gene products in formaldehyde group.
Figure 3
Figure 3
Interactions between the gene products in dioxin group.
See this image and copyright information in PMC

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